The talk will focus on handling sensitive personal data (e.g. biomedical research data) in secure computing environments. The special context is posed by data sensitivity (e.g. patient data), which has high legal and ethical requirements but also challenging computing demands. Leonhard Med, a new and powerful research IT platform developed at ETHZ and part of the national BioMedIT network, will be presented as solution for secure computing environments. When handling sensitive personal data, particular attention must be given to research data management. The Swiss national regulation will be put in the concrete context of data-driven personalized health research, guidelines on data classification will be introduced and best practices for secure handling of sensitive data along the entire data life-cycle, from data collection, data management and computational analysis to publication in repositories and long-term preservation will be shared.